![]() Oxymorphone extended-release tablets are indicated for the management of chronic pain and only for people already on a regular schedule of strong opioids for a prolonged period. The first line treatment choices for chronic pain are non-pharmacological and non-opioid agents. For any chronic treatment of pain, clinicians should only consider long term use if there is significant clinical benefit to the patient's therapy that outweigh any potential risk. Oxymorphone Immediate Release is indicated for the relief of moderate to severe pain, such as treatment of acute post surgical pain. Generic versions of extended-release oxymorphone, such as those manufactured by Amneal Pharmaceuticals, are still available in the US. Endo responded by voluntarily removing Opana ER from the market a month later. ![]() This was in part due to the opioid epidemic in the US, and the fact that a 2012 reformulation failed to stop illicit injection of the drug. In June 2017 the FDA asked Endo Pharmaceuticals to remove its product from the US market. It was patented in 1955 and approved for medical use in 1959. Like oxycodone, which metabolizes to oxymorphone, oxymorphone has a high potential to be abused. The elimination half-life of oxymorphone is much faster intravenously, and as such, the drug is most commonly used orally. ![]() Pain relief after injection begins after about 5–10 minutes, after oral administration it begins after about 30 minutes, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets. Oxymorphone (sold under the brand names Numorphan and Opana among others) is a highly potent opioid analgesic indicated for treatment of severe pain. ![]()
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